Closed-Loop Therapy

Automated drug delivery systems for personalized, precision medicine

Closed-loop control in chemotherapy

Closed-loop automated drug infusion regulator: A clinically translatable, closed-loop drug delivery system for personalized drug dosing.

Closed-loop drug delivery system
Figure. Chemotherapies are commonly dosed based on a patient's body surface area (BSA) or weight, which fails to account for the many other sources of pharmacokinetic variability between patients. These sources of pharmacokinetic variability are ignored in standard clinical practice and can result in suboptimal dosing, which can reduce efficacy and increase toxicity. The authors have developed a medical device that could enable physicians to control the concentration of the drugs in their patient's blood regardless of the many factors that could alter the pharmacokinetics for a patient. This medical device could potentially be rapidly translated to the clinic, where it may be able to decrease the toxicity and increase the efficacy of chemotherapies given to patients.

All-in-one insulin pen

An automated all-in-one system for carbohydrate tracking, glucose monitoring, and insulin delivery.

All-in-one insulin pen system
Figure. Pre-prandial insulin delivery. (a) Standard procedures to inject insulin with a safe dose based on food coverage and high blood sugar correction: 1) Estimating food serving size; 2) counting total carbohydrate content; 3) warming up the finger; 4) pricking the fingertip; 5) squeezing for blood drop; 6) measuring blood glucose; 7) calculating insulin dose; 8) dialing the insulin pen; 9) subcutaneous injection.

(b) The proposed image-based food carbohydrate estimation system for automating carbohydrate counting. (c) The all-in-one vacuum/strip pen system with lancing device, blood glucose meter, and insulin pump for autonomous glucose measurement and prandial insulin delivery. (d) All-in-one needle pen system matching commercially available insulin pen size, able to measure glucose and deliver insulin through the same needle.

Related Publications

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